WCSE

Analysis and Comparison of Polyproteins of Foot-and-Mouth Disease Virus (FMDV) Type O, A, and Asia-1, Using Apriori Algorithm and Decision Tree

Abstract— The Foot-and-Mouth Disease (FMD) is a highly infectious viral disease that is common among not only domesticated animals but also wild animals. Its several symptoms include high fever and blisters. FMD is caused by Foot-and-Mouth Disease Virus (FMDV), and it has seven serotypes: O, A, C, SAT-1, SAT-2, SAT-3, Asia-1. Among these types, type O, A, and Asia-1 are endemic to Southeast asian region. Recently, in South Korea, FMDV type O and A occurred simultaneously for the first time, bringing big disorder in stockbreeding farmhouses. FMDV type O and A showed significant difference in their spreading speed. In addition to type O and A, it was found that type Asia-1 also shows different spreading speed. We hypothesized that the cause of different spreading speed lies on the different amino acid structures of FMDV type O, A, and Asia-1, and conducted experiments to prove heterogeneity between three types of FMDV. Our experiments include two methods: Apriori algorithm and decision tree. We extracted results that showed the significant differences of the three types of FMDV, mainly focusing on positions and frequencies of amino acids of polyproteins in each of the 3 categories we have chosen. We divided the amino acid sequences in polyprotein up into 17, 13, and 9 windows. Through these experiments, we proved our hypothesis and presented a very probable conclusion that one of the possible causes of different spreading speed can lie on the different amino acid structures. Moreover, we suggested necessity of further research about vaccines that are specialized to different types of FMDV in order to increase the efficiency of vaccines.

Index Terms— FMD(Foot-and-Mouth Disease), FMDV(Foot-and-Mouth Disease Virus), FMDV type O(Foot-and-Mouth Disease Virus type O), FMDV type A(Foot-and-Mouth Disease Virus type A), FMDV type Asia-1(Foot-and-Mouth Disease Virus type Asia-1), Apriori algorithm, Decision Tree

Minkyoung Kang, Jiwon Park, Taeseon Yoon
International, Hankuk Academy of Foreign Studies, KOREA

ISBN: 978-981-11-3671-9 DOI: 10.18178/wcse.2017.06.17Xsrc="http://www.wcse.org/uploadfile/2019/0823/20190823055609629.png" style="width: 120px; height: 68px;" />[Download]

Cite: Minkyoung Kang, Jiwon Park, Taeseon Yoon, "Analysis and Comparison of Polyproteins of Foot-and-Mouth Disease Virus (FMDV) Type O, A, and Asia-1, Using Apriori Algorithm and Decision Tree," Proceedings of 2017 the 7th International Workshop on Computer Science and Engineering, pp. 1368-1372, Beijing, 25-27 June, 2017.